Special Senses: sudden decrease or loss of hearing, mydriasis, conjunctivitis, photophobia, tinnitus, eye pain, ear pain, eye hemorrhage, cataract, dry eyes.
The inhibition of PDE5 in these tissues by sildenafil may be the basis for the enhanced platelet antiaggregatory activity of nitric oxide observed in vitro, an inhibition of platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Viagra may not work as quickly if you take it with a high-fat meal.
In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance.
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Sildenafil citrate is designated chemically as 1 - [[3 - (6,7 - dihydro - 1 - methyl - 7 - oxo - 3 - propyl - 1H - pyrazolo[4,3 - d]pyrimidin - 5 - yl) - 4 - ethoxyphenyl]sulfonyl] - 4 - methylpiperazine citrate and has the following structural formula: Sildenafil citrate is a white to off-white crystalline powder with a solubility of 3.
This finding is consistent with the inhibition of PDE6, which is involved in phototransduction in the retina.
Viagra is to be used only by the patient for whom it is prescribed.
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It works by dilating blood vessels in the penis, allowing the inflow of blood needed for an erection.
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Nervous: ataxia, hypertonia, neuralgia, neuropathy, paresthesia, tremor, vertigo, depression, insomnia, somnolence, abnormal dreams, reflexes decreased, hypesthesia.
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Sexual function data were also recorded by patients in a daily diary.
Therefore sexual activity may not be advisable for people who have heart problems.
Viagra may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects.
Viagra is only for patients with erectile dysfunction.
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There were no episodes of syncope reported in this study.
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Take it only before sexual activity.
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Less common side effects that may occur are temporary changes in color vision (such as trouble telling the difference between blue and green objects or having a blue color tinge to them), eyes being more sensitive to light, or blurred vision.
Hemic and Lymphatic: anemia and leukopenia.
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Pharmacodynamics Effects of Viagra on Erectile Response In eight double-blind, placebo-controlled crossover studies of patients with either organic or psychogenic erectile dysfunction, sexual stimulation resulted in improved erections, as assessed by an objective measurement of hardness and duration of erections (RigiScan®), after Viagra administration compared with placebo.
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If you become pregnant, contact your doctor.
You should call a doctor immediately if you ever have an erection that lasts more than 4 hours.
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Use barrier methods of birth control (eg, condoms) if you have HIV infection or an STD.
In rare instances, men taking PDE5 inhibitors (oral erectile dysfunction medicines, including Viagra) reported a sudden decrease or loss of vision in one or both eyes.
Nitrates, such as nitroglycerin (e.
Even though this total dosage produced plasma sildenafil concentrations which were approximately 2 to 5 times higher than the mean maximum plasma concentrations following a single oral dose of 100 mg in healthy male volunteers, the hemodynamic response to exercise was preserved in these patients.
The penis then expands and hardens.
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Pharmacokinetics and Metabolism Viagra is rapidly absorbed after oral administration, with a mean absolute bioavailability of 41% (range 25–63%).
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Larger effects were recorded among patients receiving concomitant nitrates (see CONTRAINDICATIONS).
Contact your doctor or seek medical attention right away if you experience these symptoms.
One-third to one-half of the subjects in these studies reported successful intercourse at least once during a 4-week, treatment-free run-in period.
Effects of Viagra on Blood Pressure Single oral doses of sildenafil (100 mg) administered to healthy volunteers produced decreases in sitting blood pressure (mean maximum decrease in systolic/diastolic blood pressure of 8.
Pulmonary veno-occlusive disease (high blood pressure in the blood vessels of the lungs)—May make heart problems worse in patients with this serious condition Special patient directions come with sildenafil.
Keep Viagra out of the reach of children and away from pets.
If you experience a loss of vision in one or both eyes, stop using Viagra and seek medical attention immediately.
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Pregnancy Category B No evidence of teratogenicity, embryotoxicity or fetotoxicity was observed in rats and rabbits which received up to 200 mg/kg/day during organogenesis.
Most important fact about Viagra Viagra causes erections only during sexual excitement.
The primary endpoint was time to limiting angina in the evaluable cohort.
You will need to discuss the benefits and risks of using Viagra while you are pregnant.
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For the 17 subjects who received Viagra 25 mg and matching placebo, the placebo-subtracted mean maximum decreases from baseline (95% CI) in systolic blood pressure were as follows: Blood pressure was measured immediately pre-dose and at 15, 30, 45 minutes, and 1, 1.
Tell your doctor about any medicines you are taking.
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Most, but not all, of these patients had preexisting cardiovascular risk factors.
In a double-blind study, 144 patients with erectile dysfunction and chronic stable angina limited by exercise, not receiving chronic oral nitrates, were randomized to a single dose of placebo or Viagra 100 mg 1 hour prior to exercise testing.
It is not possible to determine whether these reported events are related directly to the use of Viagra, to the patient’s underlying risk factors for hearing loss, a combination of these factors, or to other factors (see PRECAUTIONS, Information for Patients).
Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides.
Patients 65 years of age and older who are taking this medicine for erectile dysfunction are started on a low dose, 25 mg, of sildenafil.
Symptoms of a heart attack may include chest, shoulder, neck, or jaw pain; numbness of an arm or leg; severe dizziness, headache, nausea, stomach pain, or vomiting; fainting; or vision changes.