Studies have produced relevant data on the effects of Viagra on cardiac output.
Do not take Viagra if you are also using a nitrate drug for chest pain or heart problems.
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If you need emergency medical care for a heart problem, it is important that your healthcare provider knows when you last took sildenafil.
This includes prescription and nonprescription medicines or remedies: Remember, Viagra should never be used with medicines that contain nitrates (see Viagra Is Not for Everyone).
Sexual function data were also recorded by patients in a daily diary.
Viagra is not for newborns, children, or women.
Before you start any treatment for erectile dysfunction, ask your doctor if your heart is healthy enough to handle the extra strain of having sex.
Both sildenafil and the metabolite have terminal half lives of about 4 hours.
One randomized, double-blind, placebo-controlled, crossover, flexible-dose (up to 100 mg) study of patients with erectile dysfunction resulting from spinal cord injury (n=178) was conducted.
The following information includes only the average doses of sildenafil.
In humans, Viagra has no effect on bleeding time when taken alone or with aspirin.
Viagra®, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient.
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This helps you to achieve and maintain an erection.
If you are taking medicines called alpha-blockers for the treatment of high blood pressure or prostate problems, your blood pressure could suddenly drop.
Both sildenafil and the metabolite have terminal half lives of about 4 hours.
The decrease in sitting blood pressure was most notable approximately 1–2 hours after dosing, and was not different than placebo at 8 hours.
Some of these side effects are more likely to occur with higher doses.
Two of the questions from the IIEF served as primary study endpoints; categorical responses were elicited to questions about (1) the ability to achieve erections sufficient for sexual intercourse and (2) the maintenance of erections after penetration.
Information for Patients Physicians should discuss with patients the contraindication of Viagra with regular and/or intermittent use of organic nitrates.
Studies have produced relevant data on the effects of Viagra on cardiac output.
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Viagra is an oral drug for male impotence, also known as erectile dysfunction (ED).
One randomized, double-blind, placebo-controlled, crossover, flexible-dose (up to 100 mg) study of patients with erectile dysfunction resulting from spinal cord injury (n=178) was conducted.
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Check with your health care provider before you start, stop, or change the dose of any medicine.
However, any medication taken in excess can have serious consequences.
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Make sure you tell your doctor if you have any other medical problems, especially: Age greater than 50 years or Coronary artery disease or Diabetes or Hyperlipidemia (excess of lipids in the blood) or Hypertension (high blood pressure) or Low cup to disc ratio (“crowded disc”) or Smoking—These conditions may increase risk for a serious eye problem called NAION.
Its affects during pregnancy and breastfeeding have not been studied.
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Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil, so that the metabolite accounts for about 20% of sildenafil's pharmacologic effects.
PDE5 inhibitors, including Viagra, and alpha-adrenergic blocking agents are both vasodilators with blood pressure lowering effects.
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7 seconds for sildenafil (N=70) and placebo, respectively.
Alert your doctor to the problem as soon as possible.
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Hepatic Insufficiency In volunteers with hepatic cirrhosis (Child-Pugh A and B), sildenafil clearance was reduced, resulting in increases in AUC (85%) and Cmax (47%) compared to age-matched volunteers with no hepatic impairment.
These treatments include pills, medicines that are injected or inserted into the penis, implants or vacuum pumps.
If you want more information or develop any side effects or symptoms you are concerned about, call your doctor.
Subjects who had successfully completed the previous doxazosin interaction study (using Viagra 50 mg), including no significant hemodynamic adverse events, were allowed to skip dose period 1.
Viagra had no effect on ritonavir pharmacokinetics (see DOSAGE AND ADMINISTRATION).
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If you have prostate problems or high blood pressure for which you take medicines called alpha blockers, your doctor may start you on a lower dose of Viagra.
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In the following patients: age >65, hepatic impairment (e.
If needed, your doctor may increase your daily dose to 100 mg or decrease your daily dose to 25 mg.
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Do not take Viagra if you are also using a nitrate drug for chest pain or heart problems.
Do not take Viagra more than once per day.
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It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors (see ADVERSE REACTIONS, CLINICAL TRIALS and POST-MARKETING EXPERIENCE).
Viagra may not work as quickly if you take it with a high-fat meal.
Patients with heart problems who take Viagra may be at increased risk for heart-related side effects, including heart attack or stroke.
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Renal Insufficiency In volunteers with mild (CLcr=50–80 mL/min) and moderate (CLcr=30–49 mL/min) renal impairment, the pharmacokinetics of a single oral dose of Viagra (50 mg) were not altered.
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Data from subjects exposed to high systemic levels of sildenafil are limited.
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Do not use more of it and do not use it more often than your doctor ordered.
Pulmonary veno-occlusive disease (high blood pressure in the blood vessels of the lungs)—May make heart problems worse in patients with this serious condition Special patient directions come with sildenafil.