If any develop or change in intensity, inform your doctor as soon as possible.
It is important to tell your doctor about any heart problems you may have now or may have had in the past.
Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance.
Viagra can help you have an erection when sexual stimulation occurs.
How should you take Viagra?
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Taking Viagra with a nitrate medicine can cause a serious decrease in blood pressure, leading to fainting, stroke, or heart attack.
Many of these events were reported to occur during or shortly after sexual activity, and a few were reported to occur shortly after the use of Viagra without sexual activity.
You could get dizzy or faint.
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Special Senses: sudden decrease or loss of hearing, mydriasis, conjunctivitis, photophobia, tinnitus, eye pain, ear pain, eye hemorrhage, cataract, dry eyes.
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The mean subject age was 66.
Do not store in the bathroom.
You will not get an erection just by taking the pill.
Take Viagra exactly as it was prescribed for you.
You should call a doctor immediately if you ever have a prolonged erection that lasts more than 4 hours.
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Viagra can decrease blood flow to the optic nerve of the eye, causing sudden vision loss.
When you are taking sildenafil, it is especially important that your health care professional know if you are taking any of the following: Alpha-blockers (medicine for high blood pressure—Sildenafil when taken together with an alpha-blocker medicine may cause very low blood pressure.
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There are no adequate and well-controlled studies of sildenafil in pregnant women.
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All three were taking Viagra 100 mg, and all three reported mild adverse events at the time of reductions in standing SBP, including vasodilation and lightheadedness.
The safety and efficacy of combinations of Viagra with other treatments for erectile dysfunction have not been studied.
Alternatively, the medicine may be taken 30 minutes to 4 hours before sexual intercourse.
Protein binding is independent of total drug concentrations.
Alternatively, the medicine may be taken 30 minutes to 4 hours before sexual intercourse.
Follow your doctor's instructions.
Viagra may cause other side effects besides those listed on this sheet.
If you have chest pains, dizziness or nausea during sex, stop having sex and immediately tell your doctor you have had this problem.
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The changes from baseline in scoring on the two end point questions (frequency of successful penetration during sexual activity and maintenance of erections after penetration) were highly statistically significantly in favor of Viagra.
Its effect is more potent on PDE5 than on other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11).
The dose may be increased by a doctor as needed and tolerated.
When the smaller blood vessels in the lungs become more resistant to blood flow, the right ventricle must work harder to pump enough blood through the lungs.
Sildenafil was negative in in vitro bacterial and Chinese hamster ovary cell assays to detect mutagenicity, and in vitro human lymphocytes and in vivo mouse micronucleus assays to detect clastogenicity.
Read this information carefully before you start taking Viagra.
Allow 24 hours to pass between doses.
Sildenafil citrate is designated chemically as 1 - [[3 - (6,7 - dihydro - 1 - methyl - 7 - oxo - 3 - propyl - 1H - pyrazolo[4,3 - d]pyrimidin - 5 - yl) - 4 - ethoxyphenyl]sulfonyl] - 4 - methylpiperazine citrate and has the following structural formula: Sildenafil citrate is a white to off-white crystalline powder with a solubility of 3.
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Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance.
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NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.
Take Viagra only before sexual activity.
Sildenafil (sil-DEN-a-fil) belongs to a group of medicines that delay the enzymes called phosphodiesterases from working too quickly.
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Effects of Viagra on Cardiac Parameters Single oral doses of sildenafil up to 100 mg produced no clinically relevant changes in the ECGs of normal male volunteers.
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Precautions General The evaluation of erectile dysfunction should include a determination of potential underlying causes and the identification of appropriate treatment following a complete medical assessment.
Be sure that any discarded medicine is out of the reach of children.
Non-arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision including permanent loss of vision, has been reported rarely post-marketing in temporal association with the use of phosphodiesterase type 5 (PDE5) inhibitors, including Viagra.
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Do not use more of it and do not use it more often than your doctor ordered.
You will need to discuss the benefits and risks of using Viagra while you are pregnant.
Seek medical attention right away if any of these SEVERE side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fast or irregular heartbeat; memory loss; painful or prolonged erection; ringing in the ears; seizure; severe or persistent dizziness; severe or persistent vision changes; sudden decrease or loss of vision in one or both eyes; sudden hearing loss.
Only your doctor can decide if it is right for you.
This information is a summary only.
Hepatic Insufficiency In volunteers with hepatic cirrhosis (Child-Pugh A and B), sildenafil clearance was reduced, resulting in increases in AUC (85%) and Cmax (47%) compared to age-matched volunteers with no hepatic impairment.
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It is not possible to determine whether these events were directly related to Viagra.
The safety of Viagra is unknown in patients with bleeding disorders and patients with active peptic ulceration.
Following at least 14 consecutive days of doxazosin, Viagra 50mg or matching placebo was administered simultaneously with doxazosin 4 mg (17 subjects) or with doxazosin 8 mg (3 subjects).
If your partner may become pregnant and you wish to avoid pregnancy, be sure to use an effective form of birth control.
Sildenafil citrate is designated chemically as 1 - [[3 - (6,7 - dihydro - 1 - methyl - 7 - oxo - 3 - propyl - 1H - pyrazolo[4,3 - d]pyrimidin - 5 - yl) - 4 - ethoxyphenyl]sulfonyl] - 4 - methylpiperazine citrate and has the following structural formula: Sildenafil citrate is a white to off-white crystalline powder with a solubility of 3.
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Read the directions carefully before using the medicine .
For example: If you are older than age 65, or have serious liver or kidney problems, your doctor may start you at the lowest dose (25 mg) of Viagra.
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This is not a complete list of all side effects that may occur.
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In these cases, your doctor may want to change the dose, or other precautions may be necessary.
ther of one's self or of one's surroundings; sexual problems in men (continuing), including failure to experience a sexual orgasm; sleepiness; sores in mouth and on lips; tense muscles; tightness of chest or wheezing; trembling and shaking; vomiting; waking to urinate at night; worsening of asthma Other side effects not listed above may also occur in some patients.
A prolonged erection (priapism) can damage the penis.
In the third study, a single oral dose of Viagra 100 mg or matching placebo was administered in a 3-period crossover design to 20 generally healthy males with BPH.
Pharmacokinetics in Special Populations Geriatrics Healthy elderly volunteers (65 years or over) had a reduced clearance of sildenafil, resulting in approximately 84% and 107% higher plasma AUC values of sildenafil and its active N-desmethyl metabolite, respectively, compared to those seen in healthy younger volunteers (18–45 years).
Physicians should warn patients that prolonged erections greater than 4 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of Viagra.
It continues to work for up to 4 hours, although its action is usually less after 2 hours.
Patients with the following underlying conditions can be particularly sensitive to the actions of vasodilators including Viagra – those with left ventricular outflow obstruction (e.
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Adverse Reactions CLINICAL TRIALS Viagra was administered to over 3700 patients (aged 19–87 years) during pre-marketing clinical trials worldwide.
It does not contain all information about Viagra .