In these studies, involving about 1600 patients, analyses of patient diaries showed no effect of Viagra on rates of attempted intercourse (about 2 per week), but there was clear treatment-related improvement in sexual function: per patient weekly success rates averaged 1.
If priapism is not treated immediately, penile tissue damage and permanent loss of potency could result.
It is not meant to take the place of your doctor's instructions.
When you are taking sildenafil, it is especially important that your health care professional know if you are taking any of the following: Alpha-blockers (medicine for high blood pressure—Sildenafil when taken together with an alpha-blocker medicine may cause very low blood pressure.
During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away.
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Store at room temperature Side effects cannot be anticipated.
The time course of effect was examined in one study, showing an effect for up to 4 hours but the response was diminished compared to 2 hours.
Information for Patients Physicians should discuss with patients the contraindication of Viagra with regular and/or intermittent use of organic nitrates.
The maximum recommended dosing frequency is once per day.
Keep Viagra out of the reach of children and away from pets.
Sildenafil (sil-DEN-a-fil) belongs to a group of medicines that delay the enzymes called phosphodiesterases from working too quickly.
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In the first study, a single oral dose of Viagra 100 mg or matching placebo was administered in a 2-period crossover design to 4 generally healthy males with benign prostatic hyperplasia (BPH).
Effects of Viagra on Vision At single oral doses of 100 mg and 200 mg, transient dose-related impairment of color discrimination (blue/green) was detected using the Farnsworth-Munsell 100-hue test, with peak effects near the time of peak plasma levels.
Results with all doses have been pooled, but scores showed greater improvement at the 50 and 100 mg doses than at 25 mg.
The usual dose is 50 milligrams.
Symptoms of a stroke may include confusion, vision or speech changes, one-sided weakness, or fainting.
You and your doctor can determine the dose that works best for you.
Store this medication at room temperature away from moisture and heat.
Both sildenafil and the metabolite have terminal half lives of about 4 hours.
Viagra was evaluated primarily at doses of 25 mg, 50 mg and 100 mg in 21 randomized, double-blind, placebo-controlled trials of up to 6 months in duration, using a variety of study designs (fixed dose, titration, parallel, crossover).
Use protective measures and ask your doctor if you have any questions about this.
Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg.
No severe adverse events potentially related to blood pressure effects were reported in this group.
POST-MARKETING EXPERIENCE Cardiovascular and cerebrovascular Serious cardiovascular, cerebrovascular, and vascular events, including myocardial infarction, sudden cardiac death, ventricular arrhythmia, cerebrovascular hemorrhage, transient ischemic attack, hypertension, subarachnoid and intracerebral hemorrhages, and pulmonary hemorrhage have been reported post-marketing in temporal association with the use of Viagra.
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Viagra was effective in a broad range of ED patients, including those with a history of coronary artery disease, hypertension, other cardiac disease, peripheral vascular disease, diabetes mellitus, depression, coronary artery bypass graft (CABG), radical prostatectomy, transurethral resection of the prostate (TURP) and spinal cord injury, and in patients taking antidepressants/antipsychotics and antihypertensives/diuretics.
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Hemic and Lymphatic: anemia and leukopenia.
Across all trials, Viagra improved the erections of 43% of radical prostatectomy patients compared to 15% on placebo.
If you have heart problems severe enough to make sexual activity a danger, you should avoid using Viagra.
If needed, your doctor may increase your daily dose to 100 mg or decrease your daily dose to 25 mg.
If you suspect an overdose, seek medical attention immediately.
During 3 to 6 months of double-blind treatment or longer-term (1 year), open-label studies, few patients withdrew from active treatment for any reason, including lack of effectiveness.
Urogenital: prolonged erection, priapism (see WARNINGS), and hematuria.
The erection goes away.
Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours.
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Viagra is a phosphodiesterase inhibitor.
Therefore, the use of such combinations is not recommended.
If you experience a prolonged or painful erection for 4 hours or more, contact your doctor immediately.
Digestive: vomiting, glossitis, colitis, dysphagia, gastritis, gastroenteritis, esophagitis, stomatitis, dry mouth, liver function tests abnormal, rectal hemorrhage, gingivitis.
In the following patients: age >65, hepatic impairment (e.
Sudden loss or decrease in hearing, sometimes with ringing in the ears and dizziness, has been rarely reported in people taking PDE5 inhibitors, including Viagra.
The inhibition of PDE5 in these tissues by sildenafil may be the basis for the enhanced platelet antiaggregatory activity of nitric oxide observed in vitro, an inhibition of platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo.
There were no subjects treated with Viagra 25 mg who had a standing SBP < 85mmHg.
Taking Viagra with a nitrate medicine can cause a serious decrease in blood pressure, leading to fainting, stroke, or heart attack.
Contact your doctor or seek medical attention right away if you experience these symptoms.
Pulmonary veno-occlusive disease (high blood pressure in the blood vessels of the lungs)—May make heart problems worse in patients with this serious condition Special patient directions come with sildenafil.
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It continues to work for up to 4 hours, although its action is usually less after 2 hours.
Lower starting doses may be used and doses increased as needed and as tolerated NAION (serious eye condition) in one or both eyes, previously—May increase your chance of getting NAION again.
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When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum.
Viagra is used as needed, so you are not likely to be on a dosing schedule.
Continue to take it as directed by your doctor.
Figure 2: Mean Change from Baseline in Sitting Systolic Blood Pressure, Healthy Volunteers.
Viagra is not a hormone or an aphrodisiac.
After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the feces (approximately 80% of administered oral dose) and to a lesser extent in the urine (approximately 13% of the administered oral dose).
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