Sildenafil (sil-DEN-a-fil) belongs to a group of medicines that delay the enzymes called phosphodiesterases from working too quickly.
While there were no severe adverse events potentially related to blood pressure reported in this study, one subject reported moderate vasodilatation after both Viagra 50 mg and 100 mg.
Concomitant administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in plasma levels of sildenafil.
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Although not all of these side effects may occur, if they do occur they may need medical attention.
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There were no episodes of syncope reported in this study.
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The effect on one of the major end points, maintenance of erections after penetration, is shown in Figure 3, for the pooled results of 5 fixed-dose, dose-response studies of greater than one month duration, showing response according to baseline function.
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After patients have taken Viagra, it is unknown when nitrates, if necessary, can be safely administered.
Viagra had no effect on saquinavir pharmacokinetics.
Most important fact about Viagra Viagra causes erections only during sexual excitement.
When the smaller blood vessels in the lungs become more resistant to blood flow, the right ventricle must work harder to pump enough blood through the lungs.
NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.
Viagra is not a hormone or an aphrodisiac.
One-third to one-half of the subjects in these studies reported successful intercourse at least once during a 4-week, treatment-free run-in period.
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In volunteers with severe (CLcr=<30 mL/min) renal impairment, sildenafil clearance was reduced, resulting in approximately doubling of AUC and Cmax compared to age-matched volunteers with no renal impairment.
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Follow your doctor's instructions.
Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
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If you experience a prolonged or painful erection for 4 hours or more, contact your doctor immediately.
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Effects of Viagra on Other Drugs In vitro studies Sildenafil is a weak inhibitor of the cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 >150 µM).
Do not drive or perform other possibly unsafe tasks until you know how you react to it.
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Drug Interactions Effects of Other Drugs on Viagra In vitro studies Sildenafil metabolism is principally mediated by the cytochrome P450 (CYP) isoforms 3A4 (major route) and 2C9 (minor route).
Pulmonary veno-occlusive disease (high blood pressure in the blood vessels of the lungs)—May make heart problems worse in patients with this serious condition Special patient directions come with sildenafil.
Check with your doctor if any of these most COMMON side effects persist or become bothersome: Diarrhea; dizziness; flushing; headache; heartburn; mild, temporary vision changes (eg, blue/green color tint to vision, blurred vision, sensitivity to light); stuffy nose; upset stomach.
If you take Viagra after a high-fat meal (such as a cheeseburger and french fries), the medicine may take a little longer to start working.
Effects of Viagra on Vision At single oral doses of 100 mg and 200 mg, transient dose-related impairment of color discrimination (blue/green) was detected using the Farnsworth-Munsell 100-hue test, with peak effects near the time of peak plasma levels.
Effects of Viagra on Other Drugs In vitro studies Sildenafil is a weak inhibitor of the cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 >150 µM).
Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.
Special Senses: diplopia, temporary vision loss/decreased vision, ocular redness or bloodshot appearance, ocular burning, ocular swelling/pressure, increased intraocular pressure, retinal vascular disease or bleeding, vitreous detachment/traction, paramacular edema and epistaxis.
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Seek emergency medical attention if you think you have used too much of this medicine.
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Overdose symptoms may include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.
For the 17 subjects who received Viagra 25 mg and matching placebo, the placebo-subtracted mean maximum decreases from baseline (95% CI) in systolic blood pressure were as follows: Blood pressure was measured immediately pre-dose and at 15, 30, 45 minutes, and 1, 1.
Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers").
Do not store in the bathroom.
The most common side effects of Viagra are headache, flushing of the face, and upset stomach.
Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Also collected as part of the IIEF was information about other aspects of sexual function, including information on erectile function, orgasm, desire, satisfaction with intercourse, and overall sexual satisfaction.
eatments that cause erections (eg, medicines injected or inserted into the penis, implants or vacuum pumps) Some MEDICINES MAY INTERACT with Viagra .
It is not possible to determine whether these events were directly related to Viagra.
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Clinical Studies In clinical studies, Viagra was assessed for its effect on the ability of men with erectile dysfunction (ED) to engage in sexual activity and in many cases specifically on the ability to achieve and maintain an erection sufficient for satisfactory sexual activity.
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Ask your health care provider any questions you may have about how to use Viagra .
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Mothers who are taking this medicine for pulmonary arterial hypertension and who wish to breast-feed should discuss this with their doctor.
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Do not take Viagra if you are also using a nitrate drug for chest pain or heart problems.
It is not known if sildenafil passes into breast milk or if it could harm a nursing baby.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient.
Concomitant administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in plasma levels of sildenafil.
When Viagra is taken with a high fat meal, the rate of absorption is reduced, with a mean delay in Tmax of 60 minutes and a mean reduction in Cmax of 29%.
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This analysis was performed retrospectively, and was not powered to detect any pre-specified difference in adverse reactions.
eatments that cause erections (eg, medicines injected or inserted into the penis, implants or vacuum pumps) Some MEDICINES MAY INTERACT with Viagra .